TABLE 5.
Probability of target attainment for various predicted valproic acid daily dose using the final model.
| Dose (mg/kg/day) | AGE (year) | |||||||
|---|---|---|---|---|---|---|---|---|
| 1–2 (%) | 2–3 (%) | 3–4 (%) | 4–6 (%) | 6–8 (%) | 8–10 (%) | 10–12 (%) | ||
| ABCB1 rs3789243 AG | 15 | 21.86 | 26.17 | 32.77 | 45.32 | 59.71 | 70.36 | 73.89 |
| 20 | 78.80 | 76.77 | 77.75 | 83.3 | 83.23 | 71.60 | 55.89 | |
| 25 | 96.58 | 97.99 | 96.56 | 81.98 | 63.25 | 48.59 | 33.29 | |
| 30 | 78.14 | 73.83 | 67.23 | 54.68 | 40.29 | 29.63 | 15.26 | |
| 35 | 45.17 | 45.84 | 42.79 | 33.68 | 22.53 | 13.41 | 3.95 | |
| ABCB1 rs3789243 AA | 15 | 14.76 | 17.61 | 26.17 | 38.00 | 53.41 | 64.82 | 70.56 |
| 20 | 70.11 | 67.92 | 69.04 | 74.77 | 80.24 | 72.57 | 60.44 | |
| 25 | 95.36 | 96.13 | 96.16 | 83.45 | 67.62 | 54.08 | 39.74 | |
| 30 | 85.22 | 82.39 | 73.83 | 61.98 | 46.59 | 35.18 | 22.22 | |
| 35 | 56.36 | 54.47 | 49.82 | 42.25 | 29.24 | 19.25 | 8.60 | |
| ABCB1 rs3789243 GG | 15 | 6.44 | 7.88 | 14.43 | 28.41 | 43.55 | 55.60 | 65.66 |
| 20 | 55.96 | 54.69 | 57.69 | 64.54 | 72.46 | 70.36 | 60.70 | |
| 25 | 89.00 | 87.44 | 86.43 | 83.22 | 72.36 | 60.36 | 47.03 | |
| 30 | 92.7 | 91.48 | 85.21 | 70.47 | 56.32 | 44.40 | 30.92 | |
| 35 | 70.53 | 66.16 | 60.82 | 51.73 | 39.96 | 29.67 | 17.57 | |
Percentage represents the simulated patients who achieve target steady-state trough concentrations (50–100 mg/L) given the dose mentioned. Numbers in bold font indicate the PTA is greater than 70%.