TABLE 6.

Results of doses simulations from published population pharmacokinetic models in pediatric patients with epilepsy.

Author (publication year)	Country	Target concentration (mg/L)	Weight (kg)	Recommended dose (mg/kg/day)
Yukawa et al.(1997)	Japan	75	≤10	30–40
			10–20	20–30
			>10	10–20
Blanco Serrano et al.(1999)	Spain	60	12	35
			18	27
			21	25
			25	22
			32	20
			40	17
			50	16
Correa et al.(2008)	Mexico	60	10	50
			20	40
			30	35
			40	30
			50	25
			60	20
Ding et al.(2015)	China	50	8.4	14
			10	20
			15	15
			25	10
			≥30	5–10
Gu et al.(2021)	China	4-12 a	3.3	50
			10	50
			12.5	60
			20	50
			40	40
			60	40

^a Unbound valproic acid concentration.