Table 1. Incidence of depression in patients with cirrhosis.

Day from diagnosis (days)		Pre-diagnosis period (-720)-(-361)	Pre-diagnosis period (-360)-(-181)	Pre-diagnosis period (-180)-(-91)	Pre-diagnosis period (-90)-(-31)	Post-diagnosis period (+30)-(+89)	Post-diagnosis period (+90)-(+179)	Post-diagnosis period (+180)-(+359)	Post-diagnosis period (+360)-(+719)
Total
All patients		510,737	492,882	483,027	477,724	447,148	428,092	412,123	390,503
person-year		501,962	244,017	120,116	79,286	72,768	6,102	9,999	6,303
depression case		17,855	9,855	5,303	4,407	5,487	104,876	200,373	374,221
Incidence rate (per 100 person-year)		3.56 (3.51–3.61)	4.04 (3.96–4.12)	4.41 (4.30–4.54)	5.56 (5.40–5.72)	7.54 (7.34–7.74)	5.82 (5.67–5.97)	4.99 (4.89–5.09)	4.36 (4.29–4.42)
Incidence rate ratio (IRR)		1 (ref)	1.14 (1.11–1.16)	1.24 (1.21–1.28)	1.56 (1.52–1.61)	2.12 (2.06–2.18)	1.64 (1.59–1.68)	1.40 (1.37–1.43)	1.22 (1.21–1.24)
P-value (IRR)			< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Stratification by sex
Incidence rate (per 100 person-year)
	Male	3.11 (3.05–3.17)	3.64 (3.55–3.73)	3.98 (3.85–4.12)	5.05 (4.86–5.24)	7.51 (7.27–7.76)	5.84 (5.66–6.02)	4.94 (4.82–5.06)	4.23 (4.15–4.31)
	Female	4.53 (4.42–4.63)	4.92 (4.76–5.08)	5.37 (5.14–5.61)	6.69 (6.37–7.02)	7.60 (7.25–7.97)	5.78 (5.53–6.04)	5.09 (4.92–5.27)	4.62 (4.50–4.75)
Incidence rate ratio (IRR)
	Male	1 (ref)	1.17 (1.14–1.20)	1.28 (1.24–1.33)	1.62 (1.56–1.69)	2.41 (2.34–2.50)	1.88 (1.82–1.94)	1.59 (1.55–1.63)	1.36 (1.33–1.39)
	P-value (IRR)		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Female	1 (ref)	1.09 (1.05–1.12)	1.19 (1.13–1.24)	1.48 (1.40–1.55)	1.68 (1.60–1.76)	1.28 (1.22–1.34)	1.13 (1.09–1.17)	1.02 (0.99–1.05)
	P-value (IRR)		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	0.121
Stratification by age
Incidence rate (per 100 person-year)
	Young (<55)	2.89 (2.82–2.96)	3.26 (3.16–3.37)	3.65 (3.49–3.81)	4.48 (4.27–4.70)	6.63 (6.37–6.90)	5.04 (4.85–5.23)	4.24 (4.11–4.37)	3.59 (3.51–3.68)
	Old (> = 55)	4.16 (4.08–4.24)	4.75 (4.63–4.87)	5.12 (4.95–5.30)	6.55 (6.31–6.81)	8.41 (8.12–8.71)	6.59 (6.37–6.81)	5.75 (5.60–5.90)	5.16 (5.05–5.26)
Incidence rate ratio (IRR)
	Young (<55)	1 (ref)	1.13 (1.09–1.17)	1.26 (1.21–1.32)	1.55 (1.48–1.63)	2.29 (2.20–2.39)	1.74 (1.67–1.81)	1.47 (1.42–1.51)	1.24 (1.21–1.27)
	P-value (IRR)		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
	Old (> = 55)	1 (ref)	1.14 (1.11–1.17)	1.23 (1.19–1.28)	1.58 (1.51–1.64)	2.02 (1.95–2.10)	1.58 (1.53–1.64)	1.38 (1.34–1.42)	1.24(1.21–1.27)
	P-value (IRR)		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001