Fig 4.
Histone degradation and chromatin movement during HR in yeast. In response to DSBs, histones are ubiquitinated by ubiquitin ligases and histones are evicted from the DNA in a manner dependent on the INO80 complex. These evicted histones are degraded by the proteasome. The resulting loss of histones causes chromatin decompaction which assists in a faster homology search during HR.