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. Author manuscript; available in PMC: 2022 Dec 9.
Published in final edited form as: DNA Repair (Amst). 2021 Aug 13;107:103183. doi: 10.1016/j.dnarep.2021.103183

Fig 4.

Fig 4.

Histone degradation and chromatin movement during HR in yeast. In response to DSBs, histones are ubiquitinated by ubiquitin ligases and histones are evicted from the DNA in a manner dependent on the INO80 complex. These evicted histones are degraded by the proteasome. The resulting loss of histones causes chromatin decompaction which assists in a faster homology search during HR.