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. 2022 Dec 10;194:308–315. doi: 10.1016/j.freeradbiomed.2022.12.006

Table 2.

Urinary eicosanoids.

n-PUFA Placebo P
Baseline Early End Baseline Early End Interv Progress Interv:Progr
Leukotriene E4
 LTE4 0.17 ± 0.03 0.41 ± 0.28 0.45 ± 0.27 0.27 ± 0.09 0.3 ± 0.09 0.15 ± 0.04 0.450 0.332 0.072



Prostaglandin D2metabolites 3.65 ± 1.13 3.62 ± 0.89 3.84 ± 0.71 3.35 ± 0.55 4.65 ± 1.09 4.36 ± 1.16 0.561 0.942 0.640
 Tetranor-PGDM 2.75 ± 1.01 3.04 ± 0.78 3.3 ± 0.6 2.83 ± 0.54 4.12 ± 1.02 3.75 ± 1.13 0.543 0.911 0.504
 Tetranor-PGJM 0.79 ± 0.43 0.42 ± 0.13 0.35 ± 0.05 0.41 ± 0.07 0.41 ± 0.08 0.51 ± 0.17 0.509 0.917 0.509
 2,3-dinor-11-β-PGF2α 0.11 ± 0.05 0.17 ± 0.09 0.19 ± 0.08 0.12 ± 0.04 0.12 ± 0.04 0.11 ± 0.02 0.467 0.957 0.359



Prostaglandin E2metabolites 59.7 ± 20.5 40.1 ± 9.81 55.0 ± 13.2 82.7 ± 24.3 75.0 ± 14.5 82.6 ± 17.6 0.107 0.213 0.678
 PGE2 0.21 ± 0.06 0.27 ± 0.09 0.52 ± 0.16 1.28 ± 0.59 0.81 ± 0.22 0.87 ± 0.45 0.203 0.448 0.638
 Tetranor-PGAM 1.93 ± 0.61 1.29 ± 0.29 1.48 ± 0.3 2.71 ± 0.89 2.55 ± 0.54 2.4 ± 0.69 0.090 0.960 0.667
 Tetranor-PGEM 57.4 ± 20.0 38.3 ± 9.7 52.6 ± 12.9 77.9 ± 23.4 69.9 ± 13.6 78.8 ± 17.1 0.123 0.178 0.745
 Tetranor-PGE1 0.11 ± 0.04 0.18 ± 0.09 0.38 ± 0.2 0.73 ± 0.25 1.7 ± 1.07 0.52 ± 0.16 0.163 0.419 0.257



Prostaglandin F2αmetabolites 3.52 ± 0.77 2.64 ± 0.70 3.01 ± 0.55 3.61 ± 0.47 2.95 ± 0.47 2.76 ± 0.34 0.955 0.850 0.569
 PGF2α 1.06 ± 0.09 1.25 ± 0.18 1.8 ± 0.41 1.66 ± 0.21 1.45 ± 0.34 1.17 ± 0.16 0.481 0.643 0.158
 13,14-dihydro-15-keto PGF2α 1.42 ± 0.15 1.79 ± 0.23 2.24 ± 0.31 1.87 ± 0.39 1.54 ± 0.44 1.24 ± 0.26 0.141 0.713 0.095
 Tetranor-PGFM 2.46 ± 0.74 1.39 ± 0.65 1.2 ± 0.31 1.95 ± 0.4 1.5 ± 0.28 1.59 ± 0.26 0.612 0.887 0.636



Prostacyclin metabolite
 2,3-dinor-6-keto PGF1α 0.83 ± 0.19 0.36 ± 0.17 1.02 ± 0.22 0.81 ± 0.22 1.89 ± 0.76 1.16 ± 0.78 0.310 0.882 0.009*



Thromboxane A2metabolites 4.69 ± 1.02 4.16 ± 0.86 18.9 ± 14.5 4.45 ± 1.25 6.19 ± 2.53 4.89 ± 1.59 0.404 0.356 0.273
 TXB2 0.15 ± 0.04 0.11 ± 0.06 0.61 ± 0.43 0.34 ± 0.21 0.28 ± 0.11 0.15 ± 0.06 0.511 0.375 0.139
 2,3-dinor TXB2 1.07 ± 0.2 1 ± 0.27 4.16 ± 3.18 0.85 ± 0.25 1.27 ± 0.53 0.63 ± 0.15 0.306 0.424 0.232
 11-dehydro TXB2 2.32 ± 0.52 2.29 ± 0.46 8.25 ± 5.99 2.32 ± 0.76 3.01 ± 1.31 3.28 ± 1.53 0.488 0.326 0.367
 11-dehydro-2,3-dinor TXB2 1.15 ± 0.41 0.76 ± 0.17 5.91 ± 4.91 0.94 ± 0.24 1.63 ± 0.69 0.85 ± 0.16 0.384 0.367 0.225

Results are presented as pg/mg creatinine (mean ± SD).