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. 2022 Dec 10;194:308–315. doi: 10.1016/j.freeradbiomed.2022.12.006

Table 3.

Urinary oxidation metabolites.

n-3 PUFA Placebo P
Baseline Early End Baseline Early End Interv Progress Interv:Progr
AA oxidation 21.10 ± 3.790 20.30 ± 5.190 16.90 ± 2.720 18.50 ± 1.78 22.40 ± 2.890 25.60 ± 4.45 0.308 0.984 0.144
 5(RS)-5-F2t-IsoP 1.50 ± 0.270 1.33 ± 0.280 1.19 ± 0.230 1.42 ± 0.190 1.68 ± 0.220 2.02 ± 0.310 0.114 0.404 0.052
 5-F2c-IsoP 13.80 ± 2.780 13.70 ± 4.32 11.00 ± 2.370 12.30 ± 1.100 16.30 ± 2.210 17.60 ± 3.170 0.284 0.675 0.221
 15(RS)-F2t-IsoP 0.65 ± 0.120 0.62 ± 0.180 0.46 ± 0.120 0.66 ± 0.062 0.68 ± 0.081 0.93 ± 0.130 0.134 0.627 0.042
 15-F2t-IsoP 0.24 ± 0.047 0.22 ± 0.074 0.17 ± 0.047 0.24 ± 0.031 0.22 ± 0.026 0.31 ± 0.045 0.282 0.542 0.046
 15-epi-15-F2t-IsoP 0.41 ± 0.081 0.40 ± 0.110 0.29 ± 0.086 0.42 ± 0.041 0.46 ± 0.060 0.61 ± 0.087 0.101 0.717 0.046
 15-F2t-IsoP Metabolites 4.60 ± 0.761 4.16 ± 0.730 3.77 ± 0.339 3.81 ± 0.649 3.38 ± 0.518 4.45 ± 1.013 0.957 0.469 0.127
 2,3-dinor-15-F2t-IsoP 2.26 ± 0.340 2.08 ± 0.336 1.91 ± 0.197 1.94 ± 0.329 1.78 ± 0.299 2.29 ± 0.504 0.926 0.476 0.163
 2,3-dinor-15-epi-15-F2t-IsoP 1.94 ± 0.367 1.66 ± 0.329 1.53 ± 0.153 1.46 ± 0.298 1.25 ± 0.199 1.71 ± 0.400 0.745 0.383 0.125
 ent-2,3-dinor-5,6-dihydro-15F2t-IsoP 0.41 ± 0.069 0.42 ± 0.083 0.33 ± 0.051 0.41 ± 0.065 0.35 ± 0.056 0.46 ± 0.136 0.786 0.903 0.103
 15-A2-IsoP 0.52 ± 0.100 0.43 ± 0.064 0.46 ± 0.056 0.27 ± 0.039 0.34 ± 0.062 0.61 ± 0.132 0.770 0.014 0.046



EPA oxidation 3.05 ± 0.497 4.71 ± 0.962 4.91 ± 1.161 3.29 ± 0.739 2.85 ± 0.320 5.10 ± 1.667 0.529 0.208 0.288
 5(R)-5-F3t-IsoP 0.818 ± 0.130 1.78 ± 0.707 1.90 ± 0.581 0.82 ± 0.220 0.84 ± 0.086 1.17 ± 0.144 0.187 0.391 0.687
 5(S)-5-F3t-IsoP 1.71 ± 0.388 2.48 ± 0.513 2.63 ± 0.716 2.18 ± 0.470 1.62 ± 0.258 3.52 ± 1.550 0.992 0.219 0.291



DHA oxidation 1.37 ± 0.503 1.63 ± 0.542 2.81 ± 1.660 1.03 ± 0.182 1.49 ± 0.316 1.36 ± 0.206 0.488 0.378 0.270
 4(RS)-4-F4t-NeuroP 0.80 ± 0.011 0.10 ± 0.010 0.10 ± 0.020 0.09 ± 0.005 0.12 ± 0.015 0.11 ± 0.019 0.648 0.645 0.856
 14(RS)-14-F4t-NeuroP 1.28 ± 0.500 1.53 ± 0.550 2.71 ± 1.660 0.941 ± 0.170 1.38 ± 0.309 1.25 ± 0.200 0.483 0.374 0.271



ALA oxidation 1.11 ± 0.129 1.49 ± 0.320 1.25 ± 0.330 1.87 ± 0.690 1.34 ± 0.170 2.81 ± 1.120 0.318 0.262 0.128
 ent-16-F1t-PhytoP 0.35 ± 0.052 0.41 ± 0.130 0.31 ± 0.130 0.98 ± 0.560 0.45 ± 0.078 1.29 ± 0.606 0.151 0.230 0.133
 ent-16-epi-16-F1t-PhytoP 0.32 ± 0.043 0.34 ± 0.420 0.35 ± 0.100 0.39 ± 0.077 0.37 ± 0.061 0.76 ± 0.230 0.130 0.134 0.145
 9-F1t-PhytoP 0.14 ± 0.032 0.22 ± 0.035 0.16 ± 0.032 0.13 ± 0.018 0.20 ± 0.023 0.32 ± 0.160 0.431 0.665 0.293
 9-epi-9-F1t-PhytoP 0.12 ± 0.021 0.19 ± 0.056 0.15 ± 0.052 0.14 ± 0.036 0.16 ± 0.033 0.24 ± 0.110 0.736 0.616 0.169
 ent-16-B1-PhytoP 0.15 ± 0.043 0.28 ± 0.102 0.25 ± 0.098 0.20 ± 0.049 0.14 ± 0.040 0.17 ± 0.043 0.299 0.902 0.410
 ent-9-L1-PhytoP 0.03 ± 0.005 0.05 ± 0.002 0.04 ± 0.001 0.03 ± 0.005 0.03 ± 0.007 0.03 ± 0.005 0.472 0.375 0.396
 18(S)-18-F3t-IsoP 0.52 ± 0.130 0.45 ± 0.089 0.38 ± 0.110 0.29 ± 0.098 0.39 ± 0.052 0.42 ± 0.089 0.892 0.783 0.532

Results are presented as pg/mg creatinine (mean ± SD).