Table I.
Patient characteristics of children with MIS-C, severe COVID-19 requiring intensive care unit or step-down unit hospital care, and outpatients with mild SARS-CoV-2 infections evaluated for anti–IFN-α2 autoantibodies
| Characteristic | MIS-C (n = 199) | Severe COVID-19 (n = 168) | Mild SARS-CoV-2 infection (n = 45) |
|---|---|---|---|
| Male sex | 118 (59.3) | 83 (49.4) | 24 (53.3) |
| Age (years), median (interquartile range) | 10.9 (7.5-14.7) | 13.6 (6.3-17.2) | 5.5 (2.2-11.1) |
| Race/ethnicity | |||
| White, non-Hispanic | 63 (31.7) | 62 (36.9) | 14 (31.1) |
| Black, non-Hispanic | 74 (37.2) | 41 (24.4) | 5 (11.1) |
| Hispanic or Latino | 47 (23.6) | 46 (27.4) | 15 (33.3) |
| Other race, non-Hispanic | 8 (4.0) | 14 (8.3) | 2 (4.4) |
| Unknown | 7 (3.5) | 5 (3.0) | 9 (20.0) |
| Previously healthy | 134 (67.3) | 48 (28.6) | 42 (93)∗ |
| Preexisting condition | |||
| Obesity† | 29 (14.6) | 50 (29.8) | 8 (17.8) |
| Asthma | 22 (11.1) | 34 (20.2) | 1 (2.2) |
| Cardiovascular | 4 (2.0)‡ | 15 (8.9)§ | 0 |
| Interventions | |||
| Intensive care unit admission | 170 (85.4) | 117 (69.6) | 0 |
| Shock requiring vasopressors | 90 (45.2) | 16 (9.5) | 0 |
| Mechanical ventilation | 38 (19.1) | 60 (35.7) | 0 |
Data are presented as nos. (%) unless otherwise indicated.
∗
Among outpatients, 1 had asthma requiring inhaled steroids, 1 had sickle cell trait, and 1 had a seizure disorder.
†
Because height was not available for many outpatients, weight for age of >95% percentile for age was used as a proxy to assign potential obesity status in lieu of body mass index.
‡
Congenital heart disease (n = 4).
§
Congenital heart disease (n = 7), systemic hypertension (n = 6), acquired heart disease (n = 2).