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The composition of different siRNA NPs.
| NP formulations | Weight (μg) | |||
|---|---|---|---|---|
| siRNA/G0-C14 (ratio) |
PLGA | DSPE-PEG | DSPE-PEG-S2P (from Step 24) |
|
| S2P0 NPs | 25/250 | 2500 | 1000 | 0 |
| S2P10 NPs | 25/250 | 2500 | 900 | 100 |
| S2P30 NPs | 25/250 | 2500 | 700 | 300 |
| S2P50 NPs | 25/250 | 2500 | 500 | 500 |
