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. 2022 Jul 21;30(12):3694–3713. doi: 10.1016/j.ymthe.2022.07.014

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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mmu_lncRNA 121686 mediates I/R-induced apoptosis via miR-328-5p/HtrA3 axis

The bilateral renal arteries of PT-mmu_lncRNA 121686-WT and PT-mmu_LncRNA 121686-KO littermate mice were clamped for 28 min and then underwent reperfusion for 48 h. (A) BUN level. (B) Creatinine level. (C) H&E staining. (D) TUNEL staining. (E) Tubular damage score. (F) TUNEL-positive cells. (G) qRT-PCR analysis of the expression of mmu_lncRNA 121686. (H) qRT-PCR analysis of the expression of miRNA-328-5p. (I) Immunoblots analysis of HtrA3, caspase-3, cleaved caspase-3, and β-tubulin. (J) Grayscale analysis of western blot bands of HtrA3, caspase-3, cleaved caspase-3, and β-tubulin. Data are expressed as means ± SD (n = 6). ∗p < 0.05 versus PT-mmu_LncRNA 121686-WT with sham group. #p < 0.05 versus PT-mmu_LncRNA 121686-WT with I/R group.