Table 2.

Association of Clinical Dementia Rating sum of boxes (CDR-SOB) with quantitative proportions of African ancestry and AD neuropathological burden (n = 400).

	Model 1		Model 2		Model 3
	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
AFR	0.13 (−0.03; 0.28)	0.10	0.13 (−0.03; 0.28)	0.11	0.12 (−0.04; 0.28)	0.14
BB stage
III-IV	0.60 (−0.44; 1.63)	0.26	0.35 (−0.76; 1.46)	0.53	0.33 (−0.78; 1.45)	0.55
V-VI	7.20 (5.30; 9.10)	<0.001	6.99 (5.07; 8.92)	<0.001	7.04 (5.11; 8.97)	<0.001
CERAD score
Moderate	2.18 (0.86; 3.51)	0.001	1.93 (0.59; 3.27)	0.005	1.87 (0.52; 3.22)	0.007
Frequent	4.39 (2.68; 6.10)	<0.001	4.06 (2.33; 5.79)	<0.001	3.90 (2.12; 5.67)	<0.001

AFR global African ancestry (continuous 10% increments), BB Braak & Braak, CERAD Consortium to Establish a Registry for Alzheimer’s disease.

Model 1: Linear regression model including African Ancestry, Braak & Braak stage, and CERAD score.

Model 2: Linear regression model including African Ancestry, Braak & Braak stage, and CERAD score adjusted for age, sex, and education.

Model 3: Linear regression model including African Ancestry, Braak & Braak stage, and CERAD score adjusted for age, sex, education, and APOE4.