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. 2022 Dec 10;246:115010. doi: 10.1016/j.ejmech.2022.115010

Table 2.

In vitro antifungal activities of various statins against Mucormycosis with reported MICs ≤128 μg/mL.

S.No Statin Structure Fungus* Strain MIC
μg/mL		 References
1 Fluvastatin (FLV) Image 1 R. oryzae CBS 112.07 3.6–11 [121]
CBS 109939 2–3.125 [122]
CBS 146.90 12.5 [123]
CI 2–3.125 (<AmB:2–4) [122]
R. microsporus NRRL 514 MIC90 = 33–96 [121]
R. pusillus CN(M) 231 0.4 (<AmB:1) [121]
ETH M4920 6.25 [123]
R. miehei CBS 360.92 3.125 [123]
CBS 360.92 MIC90 = 3.6 [121]
M. racemosus WRL CN(M)304 25 [123]
M. mucedo WRL CN(M)
12034		 6.25 [123]
M. circinelloides MS 12 4 [124]
A.corymbifera SZMC 2010 MIC90 = 3.6 [121]
A. glauca SZMC 11,072 6.25 [123]
S. racemosum SZMC 2011 11–33 [121]
2. Atorvastatin (ATO) Image 2 R. oryzae CBS 109939 32 [122]
CI 64–128 [125]
CI 32 [119]
R. stolonifer SZMC 11101 64 [126]
M. circinelloides MS 12 16 [127]
S. racemosum SZMC 2011 32 [126]
M. africana NRRL 2978 8 [126]
3. Lovastatin (LOV) Image 3 R. oryzae CBS 109939 128 [120,122]
CI 32–56 [124]
CI 128 [119]
R. pusillus CN(M) 231 MIC90 = 3.6 [121]
EI and CI 1–2 [128]
R. homothallicus CI 40–56 [124]
R. miehei EI,CI 64–128 [128]
M. circinelloides CI 16–56 [124]
S. racemosum SZMC 2011 16 [126]
C. bertholletiae CI 32–40 [124]
4. Hydrolyzed lovastatin (HLOV) Image 4 R. pusillus CN(M) 231 MIC90 = 11 [121]
R. miehei CBS 360.92 MIC90 = 11 [121]
A. corymbifera SZMC 2010 MIC90 = 11 [121]
5. Rosuvastatin (ROS) Image 5 R. oryzae CBS 112.07 MIC90 = 96 [121]
R. stolonifer SZMC 11101 64 [126]
R. pusillus CN(M) 231 MIC90 = 11 [121]
R. miehei CBS 360.92 MIC90 = 11–33 [121]
A. corymbifera SZMC 2010 MIC90 = 33 [121]
S. racemosum SZMC 2011 32 [126]
M. africana NRRL 2978 8 [126]
M. circinelloides MS 12 32 [127]
6. Simvastatin (SIM) Image 6 R. oryzae CBS 109939 64 [122]
[119]
R. pusillus CN(M) 231 MIC90 = 11–33 [121]
A. corymbifera SZMC 2010 MIC90 = 96 [121]
S. racemosum SZMC 2011 8 [126]
7. Hydrolyzed simvastatin (HSIM) Image 7 R. pusillus CN(M) 231 MIC90 = 1.2–3.6 [121]
A. corymbifera SZMC 2010 MIC90 = 11 [121]
R. microsporus var. oligosporus NRRL 514 MIC90 = 33–96 [121]

CI = Clinical isolates EI = Environmental isolates, Genus Rhizopus (R. oryzae, R. homothallicus, R. stolonifer, R. microspores), Genus Rhizomucor (R. pusillus, R. miehei), Genus Mucor (M. racemosus, M. mucedo, M. circinelloides) Genus Absidia (A. corymbifera, A. glauca), Genus Mycotypha (M. Africana) Genus Syncephalastrum (S. racemosum).