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. 2022 Dec 9;13:7624. doi: 10.1038/s41467-022-33576-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The SSN was constructed using Coriobacteriia protein sequences from IMG/M database containing a pfam00196 domain (Bacterial regulatory proteins, LuxR family) and predicted to have 10–12 N-terminal TM helices. Nodes represent proteins with 95% sequence identity. SSN displayed with an alignment score of 80. Nodes are coloured based on the bacterial genera that protein sequences belong to. Coloured clusters contain LuxR sequences that either are characterized in this study or are co-localized with characterized enzymes, with their representative LuxRs and potential sensing molecules displayed.