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. 2022 Dec 9;12:21306. doi: 10.1038/s41598-022-25328-6

Table 5.

Association of polymorphic variants with RILA values.

Polymorphism Genotype (No of patients): Mean value late GU toxicity RILA ANOVA Genotype (No of patients): Mean value late GI toxicity RILA ANOVA

TGFB1

C-509T

CC (26): 33.8

CT (17): 27.7

TT (5): 43.0

p = 0.080

CC (12): 32.4

CT (5): 31.4

TT (2): 57.8

p = 0.055
TGFB1 Leu10Pro

LeuLeu (14): 34.4

LeuPro (24): 29.9

ProPro (8): 35.4

p = 0.522

LeuLeu (6): 33.5

LeuPro (10): 30.3

ProPro (2): 57.8

p = 0.050
XRCC1 Arg280His NA NA NA NA
XRCC3 Thr241Met

ThrThr (21): 32.5

ThrMet (18): 35.1

MetMet (7): 27.1

p = 0.438

ThrThr (7): 32.7

ThrMet (9): 40.2

MetMet (2): 27.5

p = 0.422

NA- not applicable.

Bolded values indicate statistically significant data or statistical trend.

GU- genitourinary; GI- gastrointestinal.