Table 1.
Diagnostic usefulness of NF-κB p65, GRO-α, and CXCR2 evaluation in differentiating unruptured intracranial aneurysm patients from individuals without vascular lesions in the brain.
| Cut-off | Youden index | AUC ± SE | Se [%] |
Sp [%] |
PPV [%] |
NPV [%] |
ACC [%] |
2-tailed p-value |
||
|---|---|---|---|---|---|---|---|---|---|---|
| CSF NF-κB p65, pg/ml | 3.73 | 0.40 | 0.734 ± 0.094 | 60 | 80 | 88 | 44 | 66 | 0.01 | |
| Serum NF-κB p65, pg/ml | 10.63 | 0.58 | 0.760 ± 0.081 | 68 | 90 | 94 | 53 | 74 | 0.001 | |
| NF-κB p65 Quotient | 0.37 | 0.58 | 0.772 ± 0.078 | 68 | 100 | 100 | 56 | 77 | < 0.001 | |
| CSF GRO-α, pg/ml | 23.00 | 0.44 | 0.760 ± 0.085 | 64 | 80 | 89 | 47 | 69 | 0.002 | |
| GRO-α Quotient | 1.60 | 0.44 | 0.728 ± 0.091 | 64 | 80 | 89 | 47 | 69 | 0.01 | |
| CSF CXCR2, ng/ml | 0.31 | 0.60 | 0.736 ± 0.119 | 100 | 60 | 88 | 100 | 90 | 0.047 | |
| CXCR2 Quotient | 2.07 | 0.52 | 0.732 ± 0.103 | 92 | 60 | 85 | 75 | 83 | 0.02 | |
ACC, diagnostic accuracy; AUC, area under the ROC curve; CSF, Cerebrospinal fluid; Cut-off (based on the highest Youden index); CXCR2, C-X-C Motif Chemokine Receptor 2; GRO-α, GRO alpha chemokine; NF-κB p65, nuclear factor kappa-B p65 subunit; NPV, negative predictive value; PPV, positive predictive value; SE, Standard Error; Se, diagnostic sensitivity; Sp, diagnostic specificity.