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. 2022 Dec 9;8:131. doi: 10.1038/s41421-022-00496-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a NAb titers against the pseudotyped SARS-CoV-2 Wuhan-1, Delta, Omicron BA.1 and BA.2 strains in the hybrid-immunity group at 1–3, 4–6, 7–9, and 10–12 months post vaccination, with the infection-only group serving as a control. The dotted line represents the limit of detection (1:5); below the limit of detection, values were set to 1:1. Error bars represent the GMT values (displayed as colored numbers in the figure) with a 95% confidence interval. Statistical significance was analyzed using the Kruskal–Wallis test. b Serum neutralizing activity measured as the GMT against the pseudotyped SARS-CoV-2 in the infection-only group and hybrid-immunity group (one, two, three, and all doses at 1–3 months post vaccination). c–f The correlations between NAb titers (GMT) and Wuhan-1 (c), Delta (d), Omicron BA.1 (e), BA.2 (f) and RBD-IgG titers in the infection-only (left) and hybrid-immunity (right) groups. Scatter plots depict the simple linear fit with 95% confidence bands, together with the Spearman correlation coefficient and 2-tailed P value. Wuhan-1, SARS-CoV-2 Wuhan-Hu-1; MPV, months post vaccination.