Fig. 1. TFEB-regulated genes are differentially expressed in MAPT p.R406W brains.

RNAseq was performed in brains from MAPT p.R406W and neuropathology-free controls and reported in Jiang et al. [19]. A Principal component analysis reveals transcriptome-wide differences between MAPT p.R406W (n = 2) and neuropathology-free control brains (n = 16). B We tested whether genes that contain a CLEAR sequence or that are differentially expressed in the presence of TFEB in vitro were differentially expressed in human brains from MAPT p.R406W carriers compared with normal controls. Volcano plot showing log2 fold change between MAPT p.R406W and control brains and the –log₁₀ p-value for each gene. Red nodes: genes with p < 0.05.