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. 2022 Dec 9;12:21313. doi: 10.1038/s41598-022-25176-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A likely interpretation of our results. 1: Thioglycollate injection initiates neutrophil-predominant peritonitis. 2: Neutrophils induce IL-1β production likely through NLRP3 inflammasome activation. 3: Released IL-1β activates endothelial cells leading to increased P-selectin expression. 4: Increased P-selectin expression results in slower neutrophil rolling and higher neutrophils extravasation.