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. 2022 Dec 9;13:7603. doi: 10.1038/s41467-022-35236-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a-b PN-SIA28 interactions with HA1 of H1, H14, and H18. (a) Overlay of PN-SIA28 bound to group 1 (H1) and group 2 (H14) HA proteins. HA1 and HA2 of H1 are colored green and cyan, and HA1 and HA2 of H14 are colored split pea and pale cyan, respectively. The CDRH3 of PN-SIA28 binding to H1 is colored magenta, and the CDRH3 of PN-SIA28 binding to H14 is colored hot pink. (b) Overlay of PN-SIA28 bound to group 1 (H1) and group 2 (H18) HA proteins. The components of the PN-SIA28/H1 HA complex are colored according to (a). HA1 and HA2 of H18 are colored lemon and green-cyan, respectively. The CDRH3 of PN-SIA28 binding to H18 is colored light pink. The key amino acids that are in contact with the CDRH3 of PN-SIA28 are shown in stick representation. c–e, PN-SIA28 interactions with HA2 of H1 (c), H14 (d), and H18 (e). The main CDR loops of PN-SIA28 that are in contact with HA are shown in cartoon representation, and the heavy chain and light chain of PN-SIA28 are colored magenta and yellow. HAs are shown in surface and cartoon representation. Only the HA residues that form hydrogen bonds with PN-SIA28 are labeled and shown in stick representation. Polar contacts are drawn as dashed lines.