Table 3.

Advantages and disadvantages of the different delivery approaches for FMT

Approaches	Advantage	Disadvantage
Nasogastric/nasoduodenal/nasojejunal	Avoids sedation Low cost	Discomfort of tube placement Risk of vomiting and aspiration Inability to evaluate mucosa or take biopsies
Capsules	No sedation risk Less invasive Can be administered in office setting	Expensive Less effective than colonoscopy Capsule burden Risks of vomiting and aspiration
Colonoscopy	Ability to evaluate mucosa and take biopsies Most effective route for treatment of rCDI	Invasive and requires sedation Standard risks of colonoscopy (discomfort, perforation, bleeding) Expensive
Enema	Low cost Less invasive and avoids sedation Easy to carry out in office or at home	Donor stool does not reach the entire colon and limited to distal colon Less effective than other routes for rCDI

FMT fecal microbiota transplantation, rCDI recurrent Clostridium difficile infection