Table 1.

Classification and status of anti-tubercular compounds in development

Drug	Class	Site of action	Development phase	References
Bedaquiline	Diarylquinoline	Mycobacterial ATPase	Marketed	[18, 146, 147, 149]
Sudapyridine (WX-081)	Diarylquinoline	Mycobacterial ATPase	2	[167]
TBAJ-876	Diarylquinoline	Mycobacterial ATPase	1	[18, 19]
TBAJ-587	Diarylquinoline	Mycobacterial ATPase	1	[160, 165]
Telacebec (Q203)	Imidazopyridine	Cytochrome BC1 complex	2	[67, 169, 170]
Delamanid	Nitroimidazole	Mycolic acid synthesis/nitric acid	Marketed	[38, 41, 42]
Pretomanid	Nitroimidazole	Mycolic acid synthesis/nitric acid	3	[16, 41, 53]
BVL-GSK098	Amido-piperidine	MymA, ethionamide enzyme activator	1	[34]
SQ109	Ethylenediamine	Mycolic acid transport MmpL3	2	[59, 60]
BTZ043	Benzothiazinone	DprE1 inhibitor, arabinoglycan synthesis	2	[78, 79]
PBTZ169	Benzothiazinone	DprE1 inhibitor, arabinoglycan synthesis	1	[76, 78]
OPC-167832	Carbostyril	DprE1 inhibitor, arabinoglycan synthesis	2	[73, 78]
TBA-7371	1,4-azaindole	DprE1 inhibitor, arabinoglycan synthesis	2	[76, 87]
Sanfetrinem	Carbapenem	Peptidoglycan synthesis	2	[97]
Moxifloxacin	Fluoroquinolone	DNA gyrase	Marketed	[182]
Fodrepodacin (SPR720)	Aminobenzimidazole	DNA gyrase B	2	[184]
VXC-486	Aminobenzimidazole	DNA gyrase B	2	[187]
Rifapentine	Rifamycin	RNA Polymerase	Marketed	[12, 138]
Linezolid	Oxazolidinone	Protein Synthesis	Marketed	[16, 99]
Sutezolid	Oxazolidinone	Protein Synthesis	2	[119–121]
Tedizolid	Oxazolidinone	Protein Synthesis	No current TB trials	[109, 111–113]
Delpazolid	Oxazolidinone	Protein Synthesis	2	[125]
TBI-223	Oxazolidinone	Protein Synthesis	1	[40]
OTB-658	Oxazolidinone	Protein Synthesis	Pre-clinical	[130, 131]
GSK656	Oxaborole	leucyl t-RNA, protein synthesis	2	[134, 135, 137]
Clofazimine	Riminophenazine	Reactive Oxygen Species	Marketed	[99, 176]
Pyrifazimine (TBI-166)	Riminophenazine	Reactive Oxygen Species	1	[66, 175, 176]
GSK2556286	Pyrimidine-2,4-dione	Cholesterol Metabolism	1	[22, 188]
FNDR-20081	Quinoline	Uncertain	Pre-clinical	-