Table 2.

Pathways of circRNAs degradation.

Degradation pathways	Location	Interacting molecule	Related disease	Reference number
Endonuclease-mediated degradation	Nuclear/cytoplasm	RNase H1, Template DNA strand / RNase L, PKR	Systemic lupus erythematosus	29,33
Ago2-mediated degradation	Nuclear	miRNA, Ago2	Chronic inflammatory pain	35–37
GW182-mediated degradation	\	GW182	\	38
m6A modification-mediated degradation	Cytoplasm	YTHDF2, HRSP12, RNase-P/MRP	Hepatocellular carcinoma	40–42
Structure-mediated degradation	Cytoplasm	G3BP1, UPF1	\	43
TMAO-mediated degradation	Cytoplasm	TMAO	Dysbacteriosis in gut	45
Exosome-mediated degradation	Extracellular space	exosomes/ microvesicles	\	48