Table 2.
PERMANOVA to examine the effect of each factor on the overall bacterial composition.
| # DLB patients | # Controls | P-value | |||
|---|---|---|---|---|---|
| Chao | Weighted UniFrac | Unweighted UniFrac | |||
| (a) | 28 | 147 | |||
| DLB | 1.0E-7* | 1.0E-7* | 1.20E-04* | ||
| (b) | 28 | 142a | |||
| DLB | 1.0E-6* | 1.0E-6* | 1.3E-4* | ||
| Age | 4.8E-3* | 1.3E-3* | 2.8E-3* | ||
| Sex | 0.045* | 0.015* | 0.15 | ||
| BMI | 0.54 | 0.43 | 0.47 | ||
| Constipation | 0.13 | 0.43 | 0.52 | ||
| PPI | 1.2E-3* | *2.6E-4* | 0.12 | ||
| (c) | 28 | – | |||
| Donepezil | 0.88 | 0.92 | 0.13 | ||
| Memantine | 0.11 | 0.20 | 0.10 | ||
P-values of three distance metrics (Chao, weighted-UniFrac, and unweighted-UniFrac) are indicated. (a) Analysis of the effect of DLB on the overall microbial composition without considering other covariates in DLB and controls. (b) Analysis of the effects of DLB, age, sex, BMI, constipation, and PPI on the overall microbial composition in DLB and controls. (c) Analysis of the effects of donepezil and memantine, drugs for dementia, on the overall microbial composition in DLB.