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. 2022 Dec 9;13:7630. doi: 10.1038/s41467-022-34910-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A A volcano plot of differentially expressed genes (DEGs) detected in HPMECs treated with 10 µg/mL of SARS-CoV-2 S at 24 hpt. B Same as A but displaying DEGs from HPMEC/ACE2 treated with 10 µg/mL SARS-CoV-2 S. Dotted lines indicate the threshold for significance. Statistical significance of DEGs was determined using a Wald test and a Benjamini-Hochberg (BH) p-value adjustment. C A STRING protein-protein interaction network of DEGs identified between S-treated and untreated conditions for HPMEC.