TABLE 2.
Lethality and immunogenicity of B. anthracis mutant strains
| Strain | Toxin components produced
|
LD50a | Antibody titer in response tob:
|
|||
|---|---|---|---|---|---|---|
| PA | EF | LF | PA | LF | ||
| Sterne | PA | EF | LF | 105 | ND | ND |
| RPE | PA | LF | 107 | ND | ND | |
| RPE346 | PA | EF346/353 | LF | 107 | ND | ND |
| RPL200 | PA | EF | >109 | 1,750 | <10 | |
| RPL686 | PA | EF | LF686 | >109 | 7,000 | 1,600 |
| RPLC2 | PA | EF346/353 | LF686 | >109 | 2,400 | 1,055 |
| RPA | EF | LF | >109 | <10 | 50 | |
| RPA163 | PA163 | EF | LF | >109 | 2,160 | 110 |
| RPA313 | PA313 | EF | LF | >109 | 5,500 | 4,300 |
| RPA705 | PA705 | EF | LF | 5 × 108 | 4,100 | 4,500 |
| RPA608 | PA608 | EF | LF | >109 | 140 | 1,880 |
a
Spores per animal.
b
Titers of antibodies against PA or LF were determined by ELISA. The values given are the reciprocal geometric mean titers of serum for 10 Swiss mice. ND, not determined.