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. 2022 Dec 6;40(1):43. doi: 10.1007/s12032-022-01900-y

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Fig. 3 — Epithelial–mesenchymal transition (EMT) in cancer metastasis: Down-regulation of E-cadherin results in loss of adherence. This results in a loss of apical-basal polarity and mesenchymal transition; thus, motility is increased and cancer metastasis is facilitated [18, 20, 22]