Table 1.

Various compounds exhibiting anticancer potential through ROS-mediated programmed cell death pathways

Cell death pathway induced	Stimulus	ROS type	Model system	References
Apoptosis	3,3′-OH curcumin	H2O2	HepG2	[67]
Apoptosis	6-gingerol	ROS	U937 & K562	[68]
Apoptosis	Arctigenin	H2O2 & O2· −	MDA-MB-231	[69]
Apoptosis	Arsenic trioxide	O2· −	HPF	[70]
Apoptosis	Artesunate	ROS	TE671 & RD18	[5]
Apoptosis	Butein	ROS	HeLa
Apoptosis		H2O2 & O2· −	HepG2 & Hep3B	[71]
Apoptosis	Cannabidiol	ROS	Molt-4 &Jurkat	[72]
Apoptosis	Capsaicin	H2O2	NB4 & Kasumi-1	[73]
Apoptosis		ROS	HepG2
Apoptosis		H2O2 & O2· −	BxPC-3 & AsPC-1
Apoptosis		ROS	Jurkat
Apoptosis	Carnosic acid	ROS	IMR-32	[74]
Apoptosis		ROS	Caski
Apoptosis		ROS	HCT116
Apoptosis	Carnosol	ROS	HCT116	[75]
Apoptosis	CAY10598	ROS	HCT116	[76]
Apoptosis	Celastrol	ROS	B16	[77]
Apoptosis	Cepharanthine	ROS	H1299 & A549	[1]
Apoptosis	Curcumin	H2O2 & O2· −	HuT-78	[8]
Apoptosis	Curcumin	O2· −	HCT-116
Apoptosis	Curcumin	ROS	L929
Apoptosis	FTY720	ROS	Jeko& Mino	[4]
Apoptosis	Gambogic acid	ROS	MDA-MB-231	[78]
Apoptosis	Glucocorticoid	H2O2	WEHI7.2
Apoptosis	Gossypol	ROS	COLO205	[79]
Apoptosis	Isoliensinine	ROS	MDA-MB-231	[80]
Apoptosis	LZ-106	O2· −	H460 & A549	[81]
Apoptosis	Methylglyoxal	O2· −	Jurkat	[82]
Apoptosis	Nimbolide	H2O2	MG63	[83]
Apoptosis	Patulin	O2· −	HCT116 & HEK293	[28]
Apoptosis	Piperlongumine	H2O2	EJ & U2OS	[84]
Apoptosis	Plumbagin	H2O2 & O2· −	A375.S2	[85]
Apoptosis	Plumbagin	ROS	EL4
Apoptosis	Resveratrol	ROS	SGC7901	[86]
Apoptosis		ROS	SUDHL4 & HBL-1
Apoptosis		O2· −	U937
Apoptosis	Rotenone	H2O2	PC12	[87]
Apoptosis	Salinomycin	ROS	PC3	[88]
Apoptosis	Salvicine	H2O2	HeLa
Apoptosis	Sanguinarine	H2O2	Jurkat& Molt-4
Apoptosis	Shikonin	O2· −	HL60	[89]
Apoptosis	Sodium selenite	ROS	HepG2	[16]
Apoptosis	Sodium selenite	ROS	HCT116 & SW480
Apoptosis	TRAIL	O2· −	Jurkat
Apoptosis	Thymoquinone	ROS	MCF-7	[90]
Apoptosis		H2O2 & O2· −	BC1
Apoptosis	Wogonin	H2O2	Jurkat
Apoptosis		H2O2	HepG2	[91]
Apoptosis	Zebularine	O2· −	Calu-6	[3]
Apoptosis	Zerumbone	ROS	K562	[92]
Autophagy/Apoptosis	Calyxin Y	H2O2	NCI-H460	[2]
Apoptosis/Autophagy	Cannabidiol	ROS	MDA-MB-231	[93]
Autophagy/Apoptosis	Carnosol	ROS	MDA-MB-231	[94]
Apoptosis/Autophagy	Celastrol	ROS	HOS & MG-63	[95]
Apoptosis/Autophagy	Colistin	ROS	N2a	[96]
Autophagy/Apoptosis	Compound K	ROS	HCT-116	[97]
Apoptosis/Autophagy	FTY720	ROS	U266	[98]
Apoptosis/Autophagy	Gambogic acid	ROS	T24	[99]
Apoptosis/Autophagy	Isoorientin	ROS	HepG2	[100]
Autophagy/Apoptosis	KIOM-C	ROS	HT1080	[101]
Apoptosis/Autophagy	MomordinIc	H2O2	HepG2	[102]
Apoptosis/Autophagy	Plumbagin	ROS	PC-3 & DU145	[103]
Apoptosis/Autophagy	Resveratrol	ROS	OVCAR-3 & Caov-3
Apoptosis/Autophagy	Sanguinarine	H2O2	U87MG & U118MG
Apoptosis/Autophagy	Sodium selenite	ROS	A549	[17]
Autophagy	2-methoxyestradiol	O2· −	U87MG & HEK293	[60]
Autophagy	Bufalin	ROS	HT-29 & Caco-2	[104]
Autophagy	Ciclopirox	ROS	Rh30 & RD	[105]
Autophagy	Cucurbitacin B	O2· −	HeLa	[106]
Autophagy		ROS	MCF-7
Autophagy	Curcumin	ROS
Autophagy	Dichloroacetate	ROS	HT29 & HCT116	[107]
Autophagy	Dihydroartemisinin	ROS	BxPC-3 & PANC-1
Autophagy	Rotenone	O2· −	U87MG & HEK293
Autophagy	Salinomycin	H2O2	SW620 & RKO	[108]
Autophagy	Sodium selenite	O2· −	U87MG & T98G	[109]
Autophagy	Ursolic acid	ROS	U87MG	[110]
Apoptosis/Necrosis	Auranofin	O2· −	HeLa
Necrosis	Salinomycin	ROS	U251MG	[111]
Necrosis	Sodium selenite	H2O2 & O2· −	Jurkat& J774.2
Necroptosis	Dimethylfumarate	ROS	CT26
Necroptosis	Lycorine	ROS	ARH-77