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. 2022 Dec 5;40(12):1722–1760. doi: 10.1038/s41587-022-01582-x

Table 3.

Total reported 2021 biopharmaceuticals global sales values

Biopharmaceutical category Reported sales value ($ billion)
Originatora recombinant proteins: mAbs 217.3
Originator recombinant proteins: non-mAbs 53.6
Covid vaccines (Comirnaty and Spikevax) 54.5
Biosimilars 11.1
Nucleic acid and engineered cell based 6.8
Total value 343.3

aOriginator’ signifies non-biosimilar.