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. 2022 Nov 2;9(12):1953–1961. doi: 10.1002/acn3.51688

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© 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(Top) Previous observational studies have found that patients infected with SARS‐CoV‐2 may experience central nervous system (CNS) damage. (Bottom) Our 2‐sample MR analyses show a causal role of COVID‐19 on the neurodegenerative diseases. MR study relies on three assumptions: (i) the instrumental variables (IVs) should be associated with the exposure (COVID‐19). (ii) the IVs should not be related to confounders. (iii) the IVs should influence the outcome (NDs) risk via the exposure, not through other pathways.