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. 2022 Nov 30;27(23):8354. doi: 10.3390/molecules27238354

Figure 2.

Figure 2

Beta-Caryophyllene reduces tumorigenic properties of A549 lung cancer cells. CDDP and BCP (12 and 25 μM) alone or in combination evaded the migration and invasion of A549 lung cancer cells (A,B). The migrated cells population from different treated cell lines were quantified at a fixed area. (C) The invaded cells were stained with Giemsa and counted in four different microscopic fields (D). Invaded cells were quantified using manual counting. Values shown are mean ± SD for three independent experiments. * p < 0.05 compared to control vs. BCP alone. ** p < 0.01 significant difference. The invaded cells were calculated as the following; 50 cells = 1 fold, as in control and the treated cells value was 75 cells, so it was calculated as 1.5 fold. Values shown are mean ± SD for three independent experiments. * p < 0.05 and ** p < 0.01 significance and high significant differences, respectively, relative to CDDP-treated cells.