Table 5.

Association between total CAC progression (yes/no) and cardiac exposure.

Exposure Variables	Univariate Model		Multivariable Model 1		Multivariable Model 2
	OR (95% CI)	p-Value	OR (95% CI)	p-Value	OR (95% CI)	p-Value
Left vs. Right-sided BC	3.36 (0.72–15.78)	0.12	3.22 (0.61–16.80)	0.16	16.55 (0.091–302.26)	0.08
Heart
Mean dose, in Gy	1.32 (0.97–1.80)	0.07	1.29 (0.91–1.84)	0.15	1.74 (0.94–3.21)	0.08
D2, in Gy	1.03 (1.00–1.06)	0.02	1.02 (0.99–1.05)	0.13	1.03 (0.98–1.07)	0.23
V2, in %	1.03 (0.99–1.05)	0.10	1.01 (0.98–1.05)	0.43	1.07 (1.01–1.12)	0.01
V5, in %	1.04 (0.97–1.11)	0.28	1.05 (0.97–1.14)	0.25	1.11 (0.98–1.26)	0.08
Left Ventricle
Mean dose, in Gy	1.20 (1.06–1.37)	0.01	1.15 (1.00–1.32)	0.04	1.29 (1.01–1.65)	0.04
D2, in Gy	1.05 (1.02–1.08)	0.01	1.04 (1.01–1.07)	0.02	1.07 (1.01–1.14)	0.03
V2, in %	1.03 (1.01–1.06)	0.01	1.03 (0.99–1.06)	0.05	1.07 (1.01–1.12)	0.01
V5, in %	1.05 (1.01–1.09)	0.02	1.04 (0.99–1.08)	0.09	1.01 (1.01–1.19)	0.02

Model 1: adjusted on age, hypertension, diabetes, and cardiovascular treatment Model 2: adjusted on baseline CAC status (zero/non-zero) and age.