Table 2.
Comparison of anthropometric and biochemical parameters at baseline, and after 3 and 12 months of ETI therapy. Data are reported as median (IQR). a: p < 0.05 vs. baseline, b: p < 0.05 vs. 3 months. n.v.: normal values.
| n.v. | Baseline | 3 Months | 12 Months | p Value | |
|---|---|---|---|---|---|
| Weight (kg) | 53 (50–58.25) | 56.6 (54.5–59.57) a | 58.2 (56.6–62.9) a,b | 0.021 | |
| BMI (kg/m2) | 20 (19.20–21.75) | 22 (20.62–23.75) a | 23.1 (21–24.8) a,b | 0.002 | |
| Glucose (mg/dL) | 70–110 | 89 (79–101.2) | 89.5 (71.25–102.5) | 88 (86–109.7) | n.s. |
| HbA1C (%) | 6.2 (5.92–7) | 5.8 (5.35–6.97) a | 5.8 (5.2–6.2) a | n.s. | |
| Insulin | 7.25 (4.10–16.53) | 7.90 (5–38) | 12.3 (5–31.8) a | n.s. | |
| Steatocrit (%) | 4.1 (2.05–6.22) | 3.1 (2.1–7.9) | 2.25 (1.7–3.45) | n.s. | |
| CRP (mg/dL) | 0–0.5 | 0.71 (0.33–2.79) | 0.33 (0.33–0.41) a | 0.30 (0.20–0.30) a | <0.0001 |
| CRP/Albumin ratio | 0.17 (0.08–0.81) | 0.08 (0.08–0.10) a | 0.07 (0.07–0.09) a,b | 0.0001 | |
| Liver Parameters | |||||
| AP (U/L) | 40–150 | 109.5 (84–146) | 133.5 (101.3–172.8) | 119 (95–172) | n.s. |
| 119 (95–172) | |||||
| Dir Bil (mg/mL) | 0–0.40 | 0.24 (0.16–0.34) | 0.36 (0.26–0.44) a | 0.33 (0.26–0.62) a | 0.007 |
| Total Bil (mg/mL) | 0.20–1.20 | 0.50 (0.31–0.66) | 0.78 (0.56–1.40) a | 0.95 (0.57–1.73) a,b | 0.003 |
| AST (U/L) | 0–34 | 20 (15–26.75) | 25.50 (20.25–34.50) a | 27.5 (17.5–40.5) a | 0.047 |
| ALT (U/L) | 0–55 | 22.5 (11.7–28.7) | 28 (22.50–53.25) a | 31.5 (20.25–47.75) a | n.s. |
| yGT (U/L) | 12–64 | 14.50 (10–20.75) | 11.50 (9.25–45.25) | 13 (10–29.75) | n.s. |
| Albumin (g/dL) | 3.5–5.2 | 4.1 (3.7–4.4) | 4.1 (4.0–4.3) a | 4.5 (4.4–4.7) a,b | <0.0001 |
| Lipids | |||||
| Total CHOL (mg/dl) | 121–232 | 134 (101–145) | 144 (114.8–152.8) a | 157.5 (135–167) a,b | 0.035 |
| HDL CHOL (mg/dL) | >40 | 56 (45.50–70) | 43 (41–53.75) a | 49 (44–66) b | n.s. |
| LDL CHOL (mg/dL) | <115 | 47 (34–84) | 79 (67–90) a | 91 (81–99) a,b | 0.0001 |
| Trig (mg/dL) | <150 | 80.50 (69.25–106.5) | 75 (66–82.50) a | 79 (62–103) b | n.s. |
| Vit. A (μg/dL) | 20–80 | 28.10 (21–36.15) | 39.75 (27.45–57.38) | 47.8 (39.2–61.8) | 0.002 |
| Vit. D (ng/mL) | 30–100 | 29.40 (22–34.80) | 25.25 (16.33–33.03) | 27.6 (22.9–34.17) | n.s. |
| Vit. E (μg/dL) | 500–1800 | 1181 (840.8–1481) | 1193 (730.4–1495) | 1316 (856.8–1803) | n.s. |
| non-HDL CHOL | <145 | 63.5 (45–104.8) | 90.5 (76–105.8) a | 97 (90–114) a,b | 0.004 |
| LDL/HDL ratio | 0.69 (0.53–2.02) | 1.79 (1.46–2.04) a | 1.93 (1.4–2.04) a | 0.005 | |
Body Mass Index (BMI); Glycated hemoglobin (HbA1C); C-reactive protein (CRP); Alkaline phosphatase (AP); Direct Bilirubin (Dir Bil); Aspartate Aminotransferase (AST); Alanine aminotransferase (ALT); Gamma-glutamyltransferase (yGT); High-density lipoprotein (HDL) cholesterol (CHOL); Low-density lipoprotein (LDL); Triglycerides (Trig); Vitamin (Vit).