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ESCRT-dependent pathway of exosome biogenesis and release. The ESCRT-dependent exosome biogenesis starts with assembling all 4 ESCRT complexes on the ubiquitin-bound cargo (Ub-cargo). The process is tightly regulated by key proteins such as Alix and syntenin. Once ESCRTs bind the Ub-cargo, TSG101 navigates the cargo inside the ILV and the Vsp4/Vta1 complex will disassemble the ESCRT 0-III complex. Tetraspanins will favour the budding of the ILV.
