Table 1.
Cytokines member of the interleukin 1 (IL-1) superfamily.
| Cytokine | FAMILY NAME | Known Structure (Uniprot ID *) |
Biological Effect | Reference |
|---|---|---|---|---|
| IL-1α | IL-1F1 | Yes (P01583) | Proinflammatory | [21,29,30,31] |
| IL-1β | IL-1F2 | Yes (P01584) | Proinflammatory | [21,29,31,32] |
| IL-1Ra (Anakinra) | IL-1F3 | Yes (P18510) | Anti-inflammatory | [21,29,33] |
| IL-18 | IL-1F4 | Yes (Q14116) | Proinflammatory | [21,34,35,36] |
| IL-33 (NF-HEV *) | IL-1F11 | Yes (O95760) | Proinflammatory | [21,34,37,38] |
| IL-36α | IL-1F6 | Yes (Q9UHA7) | Proinflammatory | [21,39,40] |
| IL-36β (IL1-H2) | IL-1F8 | No (Q9NZH7) | Proinflammatory | [21,39] |
| IL-36γ | IL-1F9 | Yes (Q9NZH8) | Proinflammatory | [21,39,41] |
| IL-36Ra | IL-1F5 | Yes (Q9UBH0) | Anti-inflammatory | [21,39,42] |
| IL-37 | IL-1F7 | Yes (Q9NZH6) | Anti-inflammatory | [21,43,44] |
| IL-38 | IL-1F10 | Yes (Q8WWZ1) | Anti-inflammatory | [21,45,46,47] |
* ID: identifier; NF-HEV: nuclear factor from high endothelial venules. Table adapted from Fields et al. [21].