Figure 2.

Tau protein isoforms. Schematic representation of the main Tau protein isoforms generated via alternative splicing. At the top, the longest Tau isoform found in humans, containing all the alternatively spliced exons. Red boxes represent the microtubule binding domain (MTBD), while the N-terminal projection domain is represented by exon 2 (orange) and exon 3 (yellow). For Big Tau (4+), Exon 6+ isoforms and W-Tau only the 2N4R isoforms are depicted, but all combinations are possible.