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. 2022 Nov 26;14(23):5831. doi: 10.3390/cancers14235831

Table 2.

Compounds that suppress GC by modulating DUBs.

Compound Structure Affected DUB IC50 (μM) Effects Ref.
Emetine graphic file with name cancers-14-05831-i001.jpg USP2 Not applicable Emetine inhibited autophagy and GC progression by blocking USP2-E2F4 interaction [19]
Almac4 graphic file with name cancers-14-05831-i002.jpg USP7 0.0015 ± 0.001 Almac4 treatment enhanced the sensitivity of GC cells to T-cell killing and inhibited GC cell proliferation by elevating p53 [26,107]
C9 graphic file with name cancers-14-05831-i003.jpg USP7 4.86 C9 suppressed proliferation of MGC-803 GC cells by decreasing MDM2 expression and thus increasing p53 and p21 levels [108]
IU1 graphic file with name cancers-14-05831-i004.jpg USP14 4.7 ± 0.7 IU1 restrained cell growth and tumor-promoting effects induced by YTHDF1 in GC cells [39,109]
Compound 19 graphic file with name cancers-14-05831-i005.jpg USP28 1.10 ± 0.02 Compound 19 bound to USP28 and inhibited malignant behaviors of GC cells by downregulating LSD1 and c-Myc [110]
Lanatoside C graphic file with name cancers-14-05831-i006.jpg USP28 Not applicable Lanatoside C suppressed cell proliferation and induced apoptosis by partially attenuating the binding between USP28 and c-Myc in GC cells [111]
Galangin graphic file with name cancers-14-05831-i007.jpg UCHL1 Not applicable Galangin-induced growth inhibitory effect in SNU-484 GC cells was accompanied by UCHL1 upregulation [112]
3,3′-Diindolylmethane graphic file with name cancers-14-05831-i008.jpg BAP1 Not applicable 3,3′-Diindolylmethane induced ferroptosis in BGC-823 GC cells by BAP1 upregulation [113]

IC50, the half maximal inhibitory concentration.