Table 2.
Compound | Structure | Affected DUB | IC50 (μM) | Effects | Ref. |
---|---|---|---|---|---|
Emetine | USP2 | Not applicable | Emetine inhibited autophagy and GC progression by blocking USP2-E2F4 interaction | [19] | |
Almac4 | USP7 | 0.0015 ± 0.001 | Almac4 treatment enhanced the sensitivity of GC cells to T-cell killing and inhibited GC cell proliferation by elevating p53 | [26,107] | |
C9 | USP7 | 4.86 | C9 suppressed proliferation of MGC-803 GC cells by decreasing MDM2 expression and thus increasing p53 and p21 levels | [108] | |
IU1 | USP14 | 4.7 ± 0.7 | IU1 restrained cell growth and tumor-promoting effects induced by YTHDF1 in GC cells | [39,109] | |
Compound 19 | USP28 | 1.10 ± 0.02 | Compound 19 bound to USP28 and inhibited malignant behaviors of GC cells by downregulating LSD1 and c-Myc | [110] | |
Lanatoside C | USP28 | Not applicable | Lanatoside C suppressed cell proliferation and induced apoptosis by partially attenuating the binding between USP28 and c-Myc in GC cells | [111] | |
Galangin | UCHL1 | Not applicable | Galangin-induced growth inhibitory effect in SNU-484 GC cells was accompanied by UCHL1 upregulation | [112] | |
3,3′-Diindolylmethane | BAP1 | Not applicable | 3,3′-Diindolylmethane induced ferroptosis in BGC-823 GC cells by BAP1 upregulation | [113] |
IC50, the half maximal inhibitory concentration.