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. 2022 Dec 4;11(23):3927. doi: 10.3390/cells11233927

Figure 1.

Figure 1

Patients with sepsis show a negative correlation between NRF2 mRNA level in peripheral blood and the severity of disease. (A) QRT-PCR detected the NRF2 mRNA level in the blood of 30 healthy controls and 30 sepsis patients at the acute and recovery stages. Paired t-test was used for data comparison between acute and recovery sepsis patients, and the NRF2 mRNA level was standardized to human housekeeping gene ACTB. (B) Correlation analysis of the APACHE II score and NRF2 mRNA level in the blood of acute sepsis patients. (C,D) Correlation analysis of TNF-α and IL-6 contents in BALFs and NRF2 mRNA level in the blood of acute sepsis patients. ** p < 0.01, *** p < 0.001.