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Nrf2 deficiency exacerbates sepsis-induced ALI and promotes inflammation in a CLP mouse model; n = 6 mice per group. (A) Histological analyses of the lung tissues in WT and Nrf2−/− mice in both the sham and CLP groups. (B) Representative lung injury scores in (A). (C,D) Western blot analyses of Nrf2 protein in WT and Nrf2−/− mice. (E,F) The expressions of inflammatory cytokines including IL-1β and TNF-α in BALFs were measured with ELISA. ** p < 0.01, *** p < 0.001.
