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. 2022 Dec 4;11(23):3927. doi: 10.3390/cells11233927

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Nrf2 deficiency inhibits CLP-induced upregulation of autophagy level in lung tissues; n = 6 mice per group. (A,B) Immunofluorescence staining of LC3 and F4/80 in the lung tissues of WT and Nrf2^−/− mice before or after CLP treatment. (C,D) Western blot analyses of autophagy-associated proteins including LC3 I, LC3 II, Beclin1, and p62 in lung tissues of each group. ** p < 0.01, *** p < 0.001. (E) Transmission electron microscopy assay detected the numbers of double-membrane autophagosomes and autolysosomes (red arrows in the pictures) in lung tissues of each group.