TABLE 2.
Bactericidal and opsonophagocytic activities of the human and murine MAbs
| Hybridoma | Isotype (CH,CL) | Lowest concn giving bactericidal activity (μg/ml)a | Lowest concn giving opsonic activity (μg/ml)b |
|---|---|---|---|
| SS269 | γ3,λ | –c | >400 |
| 207,B-4 | γ2a,κ | 1 | 1.1 |
| 208,D-5 | α,κ | – | – |
| MN14C11.6 | γ2a,κ | 0.5 | 0.2 |
a
Lowest concentration giving >50% killing of strain 44/76-SL.
b
Lowest concentration giving RB in >50% of the human PMN effector cells when using opsonized strain 44/76-SL as the target.
c
–, Negative at the highest concentration tested.