TABLE 3.
Human and murine MAb epitope specificities and variable region gene assignments
| Hybridoma | Class | Specificitya (reference) | VH family | VH germ line geneb | D gene | JH gene | VL family | VL germ line geneb | JL gene |
|---|---|---|---|---|---|---|---|---|---|
| SS269 | γ3,λ | aNGGASgq (19) | VH3a | V3-33.1 (L06618) | D3-10 | JH4 | Vλ1-b | VL-47.1 (Z73663) | JL3 |
| 207,B-4 | γ2a,κ | ASGQv | VH5 (7183)c | VHD6.96 (K02887) | D-FL16.1 | JH4 | Vκ1 | K1A5 (D00081) | JK1 |
| 208,D-5 | α,κ | ASGQ | VH5 (7183) | VHD6.96 (K02887) | D-FL16.1 | JH4 | Vκ1 | K1A5 (D00081) | JK1 |
| MN14C11.6 | γ2a,κ | ASGq (19) | VH5 (7183) | VHD6.96 (K02887) | D-SP2.1 | JH4 | Vκ1 | K5.1 (D00080) | JK1 |
a
Capital letters indicate essential amino acids of the linear epitopes, while the lowercase letters represent the amino acids that may increase binding efficiency.
b
GenBank accession numbers are given in parentheses.
c
VH5 is also named 7183.