Optimal alignment of the conserved signature sequence of members of the OppA family (Cluster 5) of bacterial SBPs (65). Residues identical for >75% of the sequences are outlined. Residues conserved as compared with those of E. coli OppA are shaded. The sequences are presented as follows: protein name:organism/residue numbers. ECOLI, E. coli; STRPN, Streptococcus pneumoniae; BACSU, Bacillus subtilis; SALTY, Salmonella typhimurium; HAEIN, H. influenzae; LACLA, Lactococcus lactis; STRLI, Streptomyces lividans; EFAEC, Enterococcus faecalis; BORBU, B. burgdorferi; TPAL, T. pallidum; TDENT, T. denticola.