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. 2022 Dec 1;11(23):7150. doi: 10.3390/jcm11237150

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Unique suspected pathogen read-pairs and unique pathogen read-pairs sequenced in the venous blood specimens, arterial blood specimens and resected tissue. A unique suspected pathogen is defined as a unique nonhuman nonredundant sequence aligned with the microbial genome database. (The microbial genome can be downloaded from (The microbial genome of Coxiella burnetii and Bartonella can be downloaded from https://www.ncbi.nlm.nih.gov/sra/PRJNA853129 accessed on 30 June 2022) When the read-pairs of the unique suspected pathogen meet the positive mNGS criteria and the identity of the suspected pathogen is in accordance with clinical manifestations, the unique pathogen is defined. The resected tissue exhibited significantly higher numbers of both unique suspected pathogen read-pairs and unique pathogen read-pairs than the blood specimens by Kruskal–Wallis one-way ANOVA. (p = 0.021, p < 0.001).