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. 2022 Nov 27;14(23):5044. doi: 10.3390/nu14235044

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of SIP on the β-catenin signaling pathway in FSK-stimulated B16F10 melanoma cells. (A) Protein expression levels of β-catenin were detected by Western blot following SIP treatment for 72 h with the indicated concentration. (B) Protein expression levels of β-catenin and MITF were detected by Western blot following preincubation with 70 nM MG132 for 4 h before adding 1 mg/mL SIP and then incubated for another two days. The densitometric analysis of β-catenin (C) and MITF (D) after MG132 treatment using Photoshop software. Results were presented as mean ± SD. Statistical analysis was performed with one-way ANOVA, followed by Tukey’s multiple comparison test (n = 3; **** p < 0.0001 compared with the forskolin-stimulated group).