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. 2022 Nov 24;23(23):14670. doi: 10.3390/ijms232314670

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Viral load and mutation composition in the S protein of major SARS-CoV-2 genetic lineages. (A) PCR threshold cycle in nasopharyngeal swab compositions in primary patients during Wuhan-, Delta-, and Omicron-dominant periods. The differences between Delta and Wuhan (p < 0.0001) and Delta and Omicron (p < 0.0001) were statistically significant. (B) Composition of mutations within the RBD of the main genetic variants during Alpha-, Beta-, Delta-, Omicron-dominant periods and endemic variants SARS-CoV-2 in Moscow. The presence of amino acid substitutions are given relative to the Wuhan reference strain.