Table 4.

Cell models and tested concentrations of ST extracts to evaluate in vitro biological activities.

Evaluated Activity	Cell Model	Tested Concentration(s)	ST Administered Product	Reference
Antioxidant	Human erythrocytes	50, 75, 100 µg/mL	Fruit aqueous extract	[49]
		0.4, 0.8, 1.6 mg/mL	Leaves aqueous extract
	Saccharomyces cerevisiae	250 µg gallic acid-equivalents/mL	Leaved hydroethanolic extract (after in vitro digestion)	[57]
	Human peripheral blood lymphocytes	11.4, 200, 400 µg/mL	Leaves aqueous extract	[59]
Antiproliferative/antitumoral	MCF-7, NCI-H460, HCT-15, HeLa, HepG2	25–400 µg/mL	Fruit methanolic extract	[32]
	HT29	0.125–4 mg/mL	Fruit (residue) supercritical, hydroethanolic and hexane extracts	[64]
	KB	0.05, 0.1, 0.2 mg/mL	Leaves aqueous extract	[66]
	HeLa, A431, A375	1.56–200 µg/mL	Leaves ethanolic extract	[17]
	RD, L20B, Vero	3.5–250 µg/mL	Leaves ethanolic, methanolic and hexane extracts	[67]
	HCT-116	3–20 mg/mL	Honeys	[19,68,69]
	LoVo	10–60 mg/mL
	U202	50, 100 µg/mL	Hydromethanolic whole plant extracts	[71]
Anti-inflammatory/immune–modulatory	Human red blood cells	50–500 µg/mL	Leaves aqueous extract	[56]
	A549/8, THP-1	0.9–59.2 µg gallic acid-equivalents/mL	Leaves methanolic extract	[75]
	MDA-MB-231	0.02–29.6 µg gallic acid-equivalents/mL		[76]
	Human fibroblasts	3.7–14.8 µg gallic acid-equivalents/mL