Table 4.
Molecular functions of proteins which are upregulated in either native carotid arteries or TEVGs (annotated according to the Gene Ontology Molecular Function database).
| Gene Ontology Term | Total Proteins | Differentially Expressed Proteins | Fold Enrichment | FDR-Corrected p Value |
|---|---|---|---|---|
| Native carotid arteries | ||||
| Laminin binding | 28 | 5 | 25.5 | 8.45 × 10−4 |
| Integrin binding | 159 | 15 | 13.5 | 7.24 × 10−10 |
| Actin binding | 451 | 35 | 11.1 | 4.67 × 10−22 |
| Collagen binding | 70 | 5 | 10.2 | 2.14 × 10−2 |
| Cytoskeletal protein binding | 1006 | 44 | 6.2 | 1.78 × 10−19 |
| Carotid vascular grafts | ||||
| Proton-transporting ATPase activity, rotational mechanism | 24 | 6 | 40.2 | 1.85 × 10−5 |
| Collagen binding | 70 | 6 | 13.8 | 1.57 × 10−3 |
| Protein folding chaperone | 68 | 5 | 11.8 | 1.31 × 10−2 |
| Unfolded protein binding | 124 | 7 | 9.1 | 3.30 × 10−3 |
| Chaperone binding | 107 | 6 | 9.0 | 1.21 × 10−2 |