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. 2022 Nov 27;11(23):3795. doi: 10.3390/cells11233795

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed regulation of CGRP and PACAP gene expression. AC: adenylate cylase, ATP: adenosine monophosphate, CaM: calmodulin, cAMP: cyclic adenosine monophosphate, CGRP: calcitonin gene-related peptide CN: calcineurin, CREB: cAMP response element-binding protein, CRTC1: CN/Cre-binding protein, GPCR: G-protein-coupled receptor, Gs: stimulatory G protein, KYNA: kynurenic acid, MAPK: mitogen-activated protein kinase, NMDAR: NMDA receptor, PACAP: pituitary adenylate cyclase activating polypeptide PKC: protein kinase C.