Table 3.
Changes in cognitive outcomes and blood biomarkers.
| Variable | ROO (n = 12) | EVOO (n = 13) | ||
|---|---|---|---|---|
| Baseline (SD) | 6 Months (SD) | Baseline (SD) | 6 Months (SD) | |
| Bodyweight (kg) | 74.3 (12.4) | 74.4 (13.1) | 85.1 (19.9) | 85.7 (21.3) |
| MMSE | 27.83 (2.17) | 28.83 (1.47) | 27.15 (2.64) | 26.92 (2.78) |
| CDR | 0.42 (0.19) | 0.13 (0.23) * | 0.38 (0.22) | 0.23 (0.26) * |
| % with CDR 0.5 | 83% | 25% | 77% | 46% |
| CDR-SOB | 2.1 (1.29) | 0.38 (0.53) *** | 1.88 (1.56) | 1.00 (1.14) *** |
| WMS-IV Logical Memory | ||||
| LM overall score | 16.3 (4.9) | 15.9 (4.4) | 12.5 (4.5) | 14.5 (5.3) * |
| %Correct | ||||
| LM I | 59.3 (18.9) | 56.3 (20.8) | 45.8 (19.6) | 52.4 (20.4) |
| LM II | 55.2 (27.0) | 50.4 (17.7) | 31.5 (24.1) # | 44.9 (31.2) * |
| LM II Recognition | 83.7 (12.3) | 88.1 (11.7) | 80.3 (16.2) | 82.5 (15.6) |
| VR I | 37.9 (5.2) | 41.3 (3.5) * | 38.9 (6.5) | 41.2 (2.7) |
| VR II | 41.3 (2.9) | 40.2 (4.6) | 42.8 (0.8) | 42.4 (2.2) |
| VR II Recognition | 3.8 (1.2) | 3.8 (1.4) | 2.2 (1.5) # | 3.7 (1.6) * |
| Blood biomarkers (pg/mL) | ||||
| Aβ40 | 265 (40) | 256 (43) | 260 (86) | 259 (75) |
| Aβ42 | 12.2 (2.0) | 11.1 (1.9) | 11.2 (3.1) | 10.3 (2.7) |
| Aβ42/Aβ40 | 0.047 (0.004) | 0.044 (0.005) * | 0.044 (0.009) | 0.040 (0.007) ** |
| Tau | 1.30 (0.42) | 1.40 (0.46) | 1.95 (0.91) # | 1.76 (0.74) |
| p-Tau181 | 2.19 (0.70) | 1.85 (0.56) | 3.67 (2.94) | 2.97 (2.08) * |
| p-Tau/t-Tau | 1.88 (0.95) | 1.53 (0.89) ** | 1.91 (1.03) | 1.62 (0.75) * |
| NFL | 16.2 (4.5) | 16.8 (4.1) | 21.8 (9.3) | 23.0 (10.2) * |
Data are presented as mean (SD). * p < 0.05, ** p < 0.01, *** p < 0.001, # p < 0.05. * Compared to baseline. # Compared to ROO at baseline.