Table 1.
Summary of Studies on Cisplatin Induced-Nausea & Vomiting.
| Herbal Medicine |
Doses | Animals | Cisplatin | Kaolin Intake |
Retching & Vomiting |
Food Intake |
Body Weight |
Mechanism of Action | Authors |
|---|---|---|---|---|---|---|---|---|---|
| Xian-Bao- Xia-Tang (XBXT) |
1 & 4 g/kg (i.p.) |
Male Mink |
Single 6 mg/kg (i.p.) |
- | ↑ | - | - | NK1R: ↓ | Qian et al., 2010 [45] |
| 1.6 g/kg (p.o.) |
Male Wistar Rat |
Single 6 mg/kg (i.p.) |
↓ | - | NS | NS | Ros, IL-1β, IL-18, NLRP3, Caspase-1: ↓ |
Meng et al., 2020 [34] |
|
| 1.6 g/kg (p.o.) |
Male Wistar Rat |
Single 6 mg/kg (i.p.) |
↓ | - | NS | NS | CD86, TNF, TRPV2, Map3k8, NLRP3 IL-1R1, IL-1β, IL-6, IL-34: ↓ | Li et al., 2020 [44] |
|
| [6]-gingerol | 50, 100, 200 mg/kg (p.o.) |
Male Mink |
Single 7.5 mg/kg (i.p.) |
- | ↓ | - | - | 5-HT, DA, Substance P: ↓ |
Qian et al., 2009 [46] |
| 10, 20, 40 mg/kg (rat) & 50, 100, 200 mg/kg (mink) (p.o.) |
Male Wistar Rat & Mink |
Single 3 mg/kg (i.p., rat), 6 mg/kg (i.p., mink) |
↓ | ↓ | - | - | 5-HT, 5-HT3, TPH-1, -2, SP, NK1R, DA, D2R, TH: ↓ | Tian et al., 2020 [43] |
|
| 50 & 100 mg/kg (p.o.) | Male SD Rat |
Single 6 mg/kg (i.p.) |
↓ | - | NS | NS | 5-HT, 5-HT3A, TPH-1, -2: ↓ MAO-A: ↑ |
Cheng et al., 2020 [35] |
|
| Ginseng Radix (GR) |
Pre-treatment: 25, 50, 100 mg/kg Post-treatment: 12.5, 25, 50 mg/kg (p.o.) |
Male SD Rat |
Single 6 or 7 mg/kg (i.p.) |
↓ | - | ↑ | ↑ | Pre-: Neutrophil, Lymphocytes, WBC: ↓ Post-: Hemoglobin, RBC: ↓ |
Raghavendran et al., 2010 [40] |
| Steamed GR: 25, 50, 100 mg/kg GS: 5, 10 mg/kg GNS: 50, 100 mg/kg (p.o.) |
Male SD Rats |
Single 6 mg/kg (i.p.) |
↓ | - | NS | ↑ | Deformity (stomach, small intestine) 25 mg/kg: ↓ 50 & 100 mg/kg: NS |
Sathyanath et al., 2013 [41] |
|
| Scutellariae Radix (SR) |
1, 3, 10 mg/kg (i.p.) | Male Wistar Rat |
Single 3, 5, 10 mg/kg (i.p.) |
↓ | - | ↑ | NS | - | Aung et al., 2004 [39] |
| 3, 10 mg/kg (i.p.) |
Male Wistar Rat |
Single 3 mg/kg (i.p.) |
↓ | - | - | - | - | Mehendale et al., 2004 [38] |
|
| Berry of Panacis Quinquefolii Radix (BPQ) |
10, 50 mg/kg (i.p.) | Male Wistar Rat |
Single 3 mg/kg (i.p.) |
↓ | - | - | - | - | Mehendale et al., 2004 [38] |
| 50, 100, 150 mg/kg (i.p.) |
Male Wistar Rat |
Single 3 mg/kg (i.p.) |
↓ | - | ↑ | - | - | Mehendale et al., 2005 [37] |
|
| Ganoderma Lucidum (GL) |
1, 3, 10 mg/kg (i.p.) | Male Wistar Rat |
Single 3 mg/kg (i.p.) |
↓ | - | ↑ | - | - | Wang et al., 2005 [36] |
|
Bacopa monnieri (BM) |
N-butanolic Fraction: 10, 20, 40 mg/kg & Methanolic Fraction: 5, 10, 20 mg/kg (i.m.) |
Male & Female Pigeon | Single 7 mg/kg (i.v.) |
- | ↓ | - | ↑ | NA: NS 5-HT, DA: ↓ |
Ullah et al., 2014 [47] |
| - | ↓ | - | NS | ||||||
| Forsythiae Fructus (FF) | 1.7 g/kg (p.o.) |
Male Wistar Rat |
Single 6 mg/kg (i.p.) |
- | ↓ | - | NS | Ros, IL-1β, IL-18, NLRP3, Caspase-1: ↓ |
Meng et al., 2021 [42] |
Abbreviations: ↑, Increase; ↓, Decrease; 5-HT, Serotonin; D2R, Dopamine D2 Receptor; DA, Dopamine; GS, Saponin; GNS, Non-Sponin; I.g, Intragastric; IL, Interleukin; I.m., Intramuscular; I.p., Intraperitoneal; NK1R, Neurokinin-1 Receptor; MPG, N-(2-mercaptopropionyl) Glycine; NA, Noradrenaline; NLRP3, NLR Family Pyrin Domain Containing 3; NS, Nonsignificant; P.o., Per Os; RBC, Red Blood Cell; ROS, Reactive Oxygen Species; TNF, Tumor Necrosis Factor; TPH, Tryptophan Hydroxylase; TRPV2, Transient Receptor Potential Vanilloid Family Type 2; WBC, White Blood Cell.