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. 2022 Nov 28;23(23):14871. doi: 10.3390/ijms232314871

Figure 2.

Figure 2

Effects of AhR antagonists on mitochondrial function. Murine BV2 microglial cells on a 96 well plate were pre-treated with 10 μM HBU651 (HBU) or 1 μM CH223191 (CH) for 24 h, stimulated with 100 ng/mL LPS for 4 h, and harvested for mitochondrial activity analysis. (A) intracellular ATP content, (B) TMRE-mediated mitochondrial membrane potential, and (C) DCF-DA-based total ROS generation. (D) Mito-Sox-based mitochondrial superoxide generation. Data are expressed as the mean ± SEM (n = 5). # p < 0.05, ### p < 0.001 vs. Control (CTL), and ** p < 0.01 vs. LPS-treated DMSO.